環(huán)匹阿尼酸是一種由霉菌產(chǎn)生的真菌毒素，包括某些種類(lèi)的青霉屬和曲霉屬。其毒性與其特異性和可逆性抑制肌內質(zhì)網(wǎng)Ca2+-ATPase的能力有關(guān)(sarcoIC50 = 0.6微米)。[1]，[2]環(huán)匹阿尼酸不抑制多種其他類(lèi)型的膜結合ATP酶。它有效抑制完整組織、平滑肌和內皮以及分離細胞中的SERCA。[3],[4]

產(chǎn)品性質(zhì)：

Cas No.:18172-33-3

別名:環(huán)匹阿尼酸,NSC 117181

化學(xué)名: (6aS,11aR,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-6a,7,11a,11b-tetrahydro-2H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9(6H)-one

Canonical SMILES:OC1=C(C(C)=O)C(N2C(C)(C)[C@@H](CC3=C4C5=CNC4=CC=C3)[C@H]5[C@@H]21)=O

分子式:C20H20N2O3

分子量:336.39

溶解度:DMF: 30 mg/ml,DMSO: 20 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml

儲存條件:Store at -20°C

注意事項：

1、為了您的安全和健康，請穿實(shí)驗服并戴一次性手套操作。

2、請根據產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。儲備液的保存方式和期限：-80°C 儲存時(shí)，請在 6 個(gè)月內使用，-20°C 儲存時(shí)，請在 1 個(gè)月內使用。

3、為了提高溶解度，請將管子加熱至37℃，然后在超聲波浴中震蕩一段時(shí)間。

References:

[1]. Seidler, N.W., Jona, I., Vegh, M., et al. Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulum. The Journal of Biological Chemisty 264(30), 17816-17823 (1989).

[2]. Uyama, Y., Imaizumi, Y., and Watanabe, M. Effects of cyclopiazonic acid, a novel Ca2+-ATPase inhibitor, on contractile responses in skinned ileal smooth muscle. British Journal of Pharmacology 106, 208-214 (1992).

[3]. Mumtaz, S., Burdyga, G., Borisova, L., et al. The mechanism of agonist induced Ca2+ signalling in intact endothelial cells studied confocally in in situ arteries. Cell Calcium 49(1-4), 66-77 (2011).

[4]. Berra-Romani, R., Raqeeb, A., Torres-Jácome, J., et al. The mechanism of injury-induced intracellular calcium concentration oscillations in the endothelium of excised rat aorta. Journal of Vascular Research 49, 65-76 (2012).