西尼地平(FRC8653)是一種L型和N型雙重鈣通道阻滯劑，具有抗高血壓、抗交感神經(jīng)和神經(jīng)保護活性。IC50值:目標:鈣通道西尼地平在高血壓患者中顯示出腎臟和血管保護作用以及改善的壓力反射敏感性。它還通過(guò)清除自由基和激活磷脂酰肌醇3-激酶途徑，在大鼠局灶性腦缺血模型中表現出神經(jīng)保護作用。

產(chǎn)品性質(zhì)：

Cas No.:132203-70-4

別名:西尼地平; FRC-8653

化學(xué)名:3-O-(2-methoxyethyl) 5-O-[(E)-3-phenylprop-2-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Canonical SMILES:CC1=C(C(C(=C(N1)C)C(=O)OCC=CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCOC

分子式:C27H28N2O7

分子量:492.52

溶解度:≥ 24.6mg/mL in DMSO

儲存條件:4°C, protect from light

注意事項：

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References:

[1]. Masuda T, Ogura MN, Moriya T, et al. Beneficial effects of L- and N-type calcium channel blocker on glucose and lipid metabolism and renal function in patients with hypertension and type II diabetes mellitus. Cardiovasc Ther. 2011 Feb;29(1):46-53. doi: 10

[2]. Morimoto S, Yano Y, Maki K, Iwasaka T. Renal and vascular protective effects of cilnidipine in patients with essential hypertension. J Hypertens. 2007 Oct;25(10):2178-83.

[3]. Takahara A, Konda T, Enomoto A, Kondo N. Neuroprotective effects of a dual L/N-type Ca(2+) channel blocker cilnidipine in the rat focal brain ischemia model. Biol Pharm Bull. 2004 Sep;27(9):1388-91.

[4]. Murai Y, Uneyama H, Ishibashi H et al. Preferential inhibition of L- and N-type calcium channels in the rat hippocampal neurons by cilnidipine. Brain Res. 2000 Jan 31;854(1-2):6-10.